Stomas- Dr.Enja Amarnath Reddy
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Thursday, October 28, 2010
Wednesday, October 27, 2010
Tuesday, October 26, 2010
Saturday, October 23, 2010
DNB Question papers
General Medicine
( January 2000 to Dec2009)
( January 2000 to Dec2009)
Paper I
1. Discuss recent advances in diagnosis and management of stroke. (25 Marks)
2. Briefly describe the following: (15 Marks each)
a. Osteoporosis prevention and management
b. Mycoplasma infection of lower respiratory tract
c. Secondary hyperparathyroidism
d. Total parenteral nutrition
e. Pathophysiologic basis of management of congestive heart failure
Paper II
1. Discuss the epidemiology, clinical features and management of hepatitis C virus
infection. (25 Marks)
2. Describe briefly: (15 Marks each)
a. Positive predictive value of a diagnostic test
b. Prognostic factors in acute pancreatitis
c. Hormone therapy in cancer
d. Diagnosis and management of aluminium phosphide poisoning
e. Galactorrhoea amenorrhoea syndrome
Paper III
1. Discuss diabetic nephropathy with reference to its stages, diagnosis and management.
(25 Marks)
2. Write short notes on: (15 Marks each)
a. Heat hyperpyrexia
b. Acute confusional state
c. Hepatorenal syndrome
d. Pulseless ventricular tachycardia
e. Management of morbid obesity
Paper IV
1.
(25 Marks)
Classify seizures. What are the drugs used in serious disorders? Outline their toxicity. 2.
a. Bartonellosis
b. Highly active antiretroviral therapy
c. Non-cardiogenic pulmonary edema
d. Lipoprotein a (LP-a)
e. Serum cardiac markers JULY 2000
Paper I
1. Discuss the etiology and pathogenesis of chronic cor pulmonale. Describe the
hemodynamic abnormalities (25 Marks)
2. Briefly describe the following: (15 Marks each)
a. Diagnostic criteria and prognostic indicators in multiple myeloma
b. Classification of eosinophilic disorders
c. Serum and tissue markers in Hepatitis B viral infection
d. Trigeminal neuralgia
e. Complications of repeated blood transfusions
Paper II
1. Describe early diagnosis and management of acute ischemic stroke. (25 Marks)
2. Describe briefly; (15 Marks each)
a. Mode of mother to child transmission of HIV infection and its prevention
b. Diagnosis and prognostic indicators in acute hemorrhagic pancreatitis
c. Risk factors and management of acute respiratory distress syndrome
d. Clinical features and diagnostic workup of diabetic nephropathy
e. Management of multidrug resistant falciparum malaria
Paper III
1. Discuss pathophysiology, risk factors and prevention of coronary artery disease. (25
Marks)
2. Write short notes on: (15 Marks each)
a. Skin as a sign of internal malignancy
b. Extra-articular manifestations of Rheumatoid arthritis
c. Leukotriene antagonists
d. Clinical features and diagnosis of leptospirosis
e. Diagnosis and management of depression
Paper IV
1. Discuss thyroid hormonogenesis and its regulation. Describe various thyroid function
tests and their alterations in thyroid and nonthyroid disorders. (25 Marks)
2. Briefly describe the following: (15 Marks each)
a. Assessment of autonomic dysfunction
b. Apoptosis
c. Beta adrenergic blockers
d. Compensation in chronic respiratory acidosis
e. Classification of myelodysplastic syndromes JUNE 2001
Paper I
1. Describe the clinical features and diagnosis of acute inflammatory demyelinating poly
neuritis. & current trends in the management. (25Marks)
2. Write short notes on: (15 marks each)
a. Hepatorenal syndrome Indian sinario.
b. Thalidomide. Newer indications.
c. Ventricular aneurysim.
d. Human genome project.
e. Immuno thrombocytopenic syndrome
Paper II
1. Classification of glomerulonephritis and approach to diagnosis. (25Marks)
2. Write short notes on: (15 marks each)
a. Diagnosis of pulmonary embolism.
b. Toxoplasm infection of CNS.
c. Spontaneous bacterial peritonitis.
d. HAART
e. Mysthenic crisis.
Paper III
1. Describe the etiopathogenesis, Diagnosis, assessment of disease activity and
principles of managent of SLE. (25Marks)
2. Write short notes on: (15 marks each)
a. Diagnosis, management of MDR TB.
b. C/F & management of OP Poisoning.
c. Pathogenesis & diagnosis of sub acute hepatic failure.
d. Tx of stable angina.
e. Hepatic enzyme induction
Paper IV
1.
Discuss pathology, pathophysiology, c/f, investigations of HOCM (25Marks) 2.
Write short notes on: (15 marks each) a. Renal tubular acidosis.
b. Fever in immunocompromised patient.
c. Causes & diagnosis of spontaneous hypoglycemia.
d. Newer vaccines in infectious diseases.
e. DECEMBER 2001
Paper I
1.
2. Write short notes on: (15 marks each)
a. Rheumatoid arthritis : Current status of management including recent advances.
b. Refampin drug interactions.
c. Pathophysiology of ARDS.
d. Managemnt of unstable angina.
e. Hyperhomocysteinemia.
Give an account of pathophysiology & management of septic shock (25Marks) Paper II
1. Discuss the etiology, predisposing factors, prevention, & management of ARF in the tropics (25Marks)
2. Write short notes on: (15 marks each)
a. DCM
b. MDRTB.
c. Diabetic retinopathy.
d. Hypertriglyceridemia.
e. Toxoplasma infection of CNS
Paper III
1. Discuss the etiopathogenesis of chronic hepatitis. Describe the clinical features,
diagnosis & management of chronic hepatitis B (25Marks)
2. Write short notes on: (15 marks each)
a. ANCA associated renal diseases.
b. Prevention of sudden cardiac death.
c. Antiplatelet agents.
d. Diagnosis & management of visceral leshmaniasis.
e. Botulinum toxins & its therapeutic value
Paper IV
1. C/f , diagnosis of high cervical cord compression (25Marks)
2. Write short notes on: (15 marks each)
a. Pathogenesis of type 2 DM.
b. Chronic alcohol abuse.
c. IBD, classification & distinguishing features.
d. Immunomodulation & its clinical applications.
e. Epidemiology of HIV JUNE 2002
Paper I
1. Principle and techniques of CPR (25Marks)
3. Write short notes on: (15 marks each)
a. Epidemiology of plague.
b. Renal osteodystrophy, pathophysiology & diagnosis.
c. Risk factors of IHD in asian male.
d. Adverse reaction to blood txn.
e. CAPD
Paper II
1. Describe the etiopathogenesis , c/f, management of antiphospholipid antibody syndrome
(25Marks)
2. Write short notes on: (15 marks each)
a. BAL.
b. TPN.
c. Therapeutic apharesis.
d. Activated protein C.
e. Raynaud’s phenomenon, classification & therapeutic approach.
Paper III
1. Describe pathogenesis, c/f, diagnosis, management of obesity. (25Marks)
2. Write short notes on: (15 marks each)
a. Postprandial hyperglycemia.
b. Reactive spondyloarthritis.
c. Atypical GERD.
d. Diagnosis, treatment of idiopathic pulmonary fibrosis.
e. Aluminium phosphide poisoning
Paper IV
1. Describe the conduction system of heart. Outline the AV conduction disturbance, their
diagnosis, management (25Marks)
2. Write short notes on: (15 marks each)
a. Atypical pneumonia.
b. Antitumour necrosis factor antibody.
c. Clinical relevance of pharmacogenetics.
d. Apoptosis.
e. Renal artery stenosis DECEMBER 2002
Paper I
1. Describe the etiology, pathology, diagnosis, recent trends in management of rheumatoid
arthritis (25Marks)
2. Write short notes on: (15 marks each)
a. Allergic bronchpulmonary aspergillosis.
b. C/f management of acute myocarditis.
c. Analgesic nephropathy.
d. Physician contribution to infection control in hospital.
e. Metabolic acidosis
Paper II
1. Discuss calcium metabolism with special reference to hyper and hypocalcemic states
(25Marks)
2. Write short notes on: (15 marks each)
a. CIDP.
b. Therapeutic strategies in unstable angina – current concept.
c. Pulmonary infiltrates.
d. RNTCP – merits and demerits.
e. Myasthenia gravis, etiopathogenesis and management
Paper III
1. Causes of ischemic stroke, describe management plan for a pt presenting with acute stroke (25Marks)
2. Write short notes on: (15 marks each)
a. Renal involvement in SLE.
b. ART indications and preferred regimens.
c. Rabdomyolysis.
d. Pharmacological stress in cardiology, their indications.
e. Invasive aspergillosis
Paper IV
1. Discuss briefly the pathogenesis of migraine, with special reference to its pharmacological
basis. Outline the therapeutic approach to a pt getting 3 to 4 attaks per month of acute
migrane of moderate severity (25Marks)
2. Write short notes on: (15 marks each)
a. Clinical approach of hyponetremia.
b. Theurapeutic options in aplastic anemia.
c. Quantitative mehods for clinical decision making.
d. Endocrine paraneoplastic syndrome.
e. Diagnosis of brain death
JUNE 2003
Paper I
1 Describe clinical fatures, invetigation and therapy for severe falciparum malaria. (25Marks)
2 Write short notes on : (15 marks each)
a. Entrapment neuropathies
b. Valsalva manoeuver
c. Criteria for diagnosis of SLE
d. Hyperpyrexia
e. Hospital acquired pneumonia
Paper II
1 Discuss myelodysplastic syndrome with special referrance to etiology, classification and
management. (25Marks)
2 Write short notes on : (15 marks each)
a. Insulin sensitizers
b. Apoptosis
c. Role of hyperhomocysteinemia in vascular disease and its treatment
d. H A A R T (Highly active antiretroviral therapy): How to monitor its effectiveness
e. Recurrent hypoglycemia
Paper III
1. Describe in detail diagnosis and management of acute myocardial infarction in first 24
hours? (25Marks)
2. Write short notes on : (15 marks each)
a. Renal invovement in DM
b. SARS
c. Opportunistic lung infection in persons with HIV
d. Antiviral therapy in chronic hepatitis
e. Magnetic resonance Angiography
Paper IV
1. Discuss the challenges of DM in 21
2. Write short notes on : (15 marks each)
a. HIV vaccine current status
b. Sleep deprivation
c. Pharmacotherapy in Dyslipidemia
d. Oncogenes
e. Cardiac biomarkers
st century in India. (25Marks) DECEMBER 2003
Paper I
1. Describe etiopathogenesis, clinical features, management of Rheumatoid Arthritis?
(25Marks)
2. Write short notes on : (15 marks each)
a. Renal Replacement therapy
b. Hypercoagulable states
c. Dengue shock syndrome
d. Key messages of JNC VII
e. Management of refractory seizures
Paper II
1 Discuss the management of ischemic cerebral stroke within two hours of onset. (25Marks)
2 Write short notes on : (15 marks each)
a. Glargine insulin
b. Noninvasive ventilation
c. Diabetic cardiomyopathy
d. Thalidomide –current status
e. Hepatorenal syndrome
Paper III
1 Discuss the hazards of prolonged alcohol consumption. (25Marks)
2 Write short notes on : (15 marks each)
a. H.pylori
b. Vitiligo
c. Noise pollution
d. Panic disorders
e. Sick euthyroid syndrome
Paper IV
1 Describe briefly various causes of hypoxia. Discuss the benefits, principles, amd modes of
use of long gterm oxygen therapy in a patient with advanced chronic obstructive pulmonary
disease. (25Marks)
2 Write short notes on : (15 marks each)
a. Age related physiologic changes and their consequences.
b. Diagnosis and management of pneumocystis carinii pneumonia in HIV positive patient
c. Diabetic nephropathy
d. Nutrional assessment
e. Anemia in chronic renal failure
DECEMBER 2004
Paper I
1. Discuss pathophysiology and management of paroxysmal supraventricular
tachycardia
2. Describe the etiopathogenesis and management of nosocomial pneumonias
3. Preservation of beta cell functions in diabetes
4. Pancreatic neuroendocrine tumors
5. Hepatorenal syndrome
6. TIA
7. Secretory diarrhoea
8. TTP
9. Perinatal transfusion of HIV. Current strategies
10.CAPD
Paper II
1. Assessment of obesity
2. Dermal leishmaniasis
3. Monoclonal antibodies in clinical use
4. Reactive arthritis
5. Lab diagnosis of Cushing’s syndrome
6. Interpretation of ABG
7. Management of lupus nephritis
8. SAARS
9. Heat stroke
10.Total parenteral nutrition
DECEMBER 2004
PAPER III
1. Thrombolytic therapy in acute stroke
2. Drugs for dyslipidemia
3. Diagnosis of malabsorption syndrome
4. Pleural fluid analysis
5. Gestational diabetes mellitus
6. NSAID induced nephropathy
7. Hypereosinophilic syndrome
8. Low dose methotrexate therapy
9. Asymptomatic hyperbilirubenemia
10. Post exposure prophylaxis of rabies
PAPER IV
1.
2. Describe and classify amyloidosis. Enlist features of amyloidosis. How would u
confirm diagnosis
3. What are GOLD guidelines for COPD.
4. Describe pathogenesis and treatment of parkinsonism
5. Define prehypertension and prediabetes. Compare JNC 6 and 7 guidelines in tabular
form
6. Bone marrow transplantation in medicine
7. Enumerate the drugs name , doses and toxicity used for resistant cerebral malaria.
Mention complications of cerebral malaria
8. (A) Enlist the pathological entities involved in cutaneous T cell lymphoma. How will
u confirm the diagnosis (B) Enumerate the skin changes in internal malignancy
9. Name systemic vasculitides. Which conditions mimic vasculitis
10.Mention possible etiologies of diabetic neuropathies.
Describe formation, functions of CSF and alterations in diseases JUNE 2005
Paper I
1. Hypoproliferative anaemia – causes , diagnosis, treatment
2. A.Chronic diarrhea; B. Frostbite
3. A.Erectile dysfunction; B. Refractory ascites
4. Discuss management of acute ischemic stroke in a patient presenting within 3-6 hours
5. Discuss briefly: a. treatment of septisemic shock; b. benign positional paroxysmal
vertigo
6. Discuss management of community acquired pneumonia
7. Discuss briefly evaluation of adult patients with seizures
8. Diagnosis and treatment of ankylosing spondylosis
9. Discuss indications and contraindications of cardiac transplantation
10.Treatment of renal hypertension
Paper II
1. Discuss current management strategies in osteoporosis
2. Discuss briefly aspirin resistance
3. Hemolytic uremic syndrome
4. Primary hyperaldosteronism
5. Management of acute gastrointestinal bleeding
6. Syndrome of Inappropriate Anti Diuretic Hormone (SIADH)
7. Myasthenia crisis
8. Risk stratification in patient with acute coronary syndrome
9. Junctional tachycardia
10.Obstructive sleep apnoea
JUNE 2005
Paper III
1. Discuss preoperative evaluation of a patient for non-cardiac surgery
2. Anorexia nervosa
3. Post traumatic stress disorder
4. Herpes zoster
5. Neuroleptic malignant syndrome
6. Transient global amnesia
7. Fluid therapy in severely hypo volumic ill patients
8. Kaposi’s sarcoma
9. Management of delirium tremens
10. Pemphigus vulgaris
Paper IV
1. Meningococcal meningitis
2. Unexplained visual loss
3. Polymerase chain reaction
4. Hyponatremia
5. Stem cell therapy for ischemic heart disease
6. Non Alcoholic Steato Hepatitis (NASH)
7. Randomised controlled trials
8. Total Renic Angiotensin Aldosterone System (RAAS) blockade.
9. Vascular endothelial dysfunction
10.Chi-square test
DECEMBER 2005
Paper I
1. Define shock. Management of different type of shocks
2. Diagnosis and management of myesthenic crisis
3. Diagnosis and management of infective endocaditis
4. Diagnosis and management of rapidly progressive renal failure
5. Causes, diagnosis and management of DIC
6. Hypokalemic paralysis
7. Causes of hypocalcemia and management
8. Bioterrorism
9. Tumor lysis syndrome
10.Management of chronic persistent asthma
Paper II
1. Genetic counseling
2. Immunonutrition in critical illness
3. Throtoxic myopathy
4. Hepatopulmonary syndrome
5. Cardiac pacing
6. Sideroblastic anemia
7. Evaluation of patient with chronic kidney disease
8. Approach of lower GI bleeding in elderly
9. Diabetic neuropathy
10.Hemorrhagic fever
DECEMBER 2005
Paper III
1. Define SIRS. pathophysiology and management
2. Management of UA/ NSTEMI
3. Chronic meniigitis
4. Psoriatic arthritis
5. Alpha 1 antitrypsin deficiency
6. Drug therapy of chronic hepatitis B
7. High altitude diseases
8. Non invasive ventilation
9. Vitamin B1
10. Sterile pyuria
Paper IV
1. Insulin resistance
2. Postprandial dyslipidemia
3. Ethical issues in clinical research
4. Spirometery
5. Descriptive and analytical epidemiology
6. Stress hyperglycemia
7. Management of ILD
8. Primary hypothyroidism
9. HUS
10.Refractory ascitis
JUNE 2006
Paper I
1. Describe causes, diagnosis and management of ARDS
2. A. Neuroparalytic snake envenomation B. Hyperbaric oxygen therapy
3. Hyponatremia: diagnosis, etiology and management
4. A. TTPC (Thrombotic thrombocytopenic purpurs) B. Indications and rationales of use
of IVIg.
5. A. Refractory heart failure B. Slow virus disease
6. Diagnosis and principles of management of DKA
7. Evaluation of patient of febrile encephalopathy
8. Classification and management of systemic vasculitis
9. Indications and management of liver transplantation
10.Diagnosis and management of acute tubular necrosis
Paper II
1. Management of acute liver failure
2. Evaluation of patient with suspected Cushing’s syndrome
3. Atrial fibrillation
4. Lupus nephritis
5. Tumor lysis syndrome
6. Newer insulin analogues
7. G6PD deficiency
8. Pulmonary illness with eosinophilia
9. Seizures in a patient with HIV infection
10. Severe falciparum malaria
JUNE 2006
Paper III
1. Diagnosis of infective endocarditis
2. Sleep apnoea syndrome
3. Antineutrophilic cytoplasmic antibodies
4. Treatment of osteoporosis
5. Henosch Schonlein purpura
6. Obsessive compulsive disorder
7. Internuclear ophthalmopathy
8. Granulomatous hepatitis
9. Diabetic foot
10.Medical adrenalectomy
Paper IV
1. Use of embryonic and somatic stem cell technology in medicine
2. Blood component therapy
3. Infections in health care workers
4. Disease modifying anti rheumatoid drugs
5. Antiphospholipid antibody syndrome
6. Quantitative medical predictors of diagnostic tests
7. Blood supply of brain and its importance in localization of site of stroke
8. Complications of mechanical ventilators
9. Medical conditions causing daytime sleepiness
10.Case control study
DECEMBER 2006
Paper I
1. Monoclonal antibodies
2. Antiphospholipid syndrome
3. Leptospirosis
4. Management of multiple myeloma
5. Myoclonic seizures
6. Natural killer cells
7. Recombinant factor VII
8. Therapeutic angiogenesis
9. Thrombolytics in acute ischemic stroke
10.Refractory ascitis
Paper II
1. Xanthogranulomatous pyelonephritis
2. CAPD catheter insertion and management of complications
3. Malarial hepatopathy
4. Plasmapheresis
5. Hyperosmolar nonketotic diabetic coma
6. Genetic councelling
7. Microscopic colitis
8. Medical management of aplastic anaemia
9. DNA vaccines
10.Diagnosis of rheumatic heart diseases
DECEMBER 2006
Paper III
1. Stem cell therapy
2. Management of ventricular arrhythmias
3. COPD diagnosis and management
4. Raynod’s phenomenon
5. Dengue fever
6. Parkinson’s disease
7. Hypercalcemia
8. Myxoedema coma
9. Drug induced nephropathy
10. Idiopathic thrombocytopenic purpura
Paper IV
1. Long QT syndrome
2. Diabetic nephropathy
3. Chronic gastritis
4. Obstructive sleep apnoea
5. Autoantibodies
6. Heat stroke
7. Standard deviation
8. Neutrogenomics
9. Artificial liver support
10.Circle of willis and clinical importance
JUNE 2007
Paper I
1. Assessing cardio-metabolic risk for metabolic syndrome
2. AIDS wasting syndrome
3. Sirolimus
4. Management of ITP in adults
5. Chikunguniya fever
6. Gestational diabetes mellitus
7. Immune Reconstitution Inflammatory Syndrome
8. Diagnostic approach to abdominal tuberculosis
9. Management of painful neuropathy
10. Pulmonary vasculitis
Paper II
1. Management of acute severe asthma
2. Evaluation of malabsorption
3. Prosthetic valve endocarditis
4. Diabetic nephropathy
5. Anticytokine agents in rheumatoid arthritis
6. Reticulocyte Proliferation Index
7. Paraneoplastic neurologic syndromes
8. Weil’s syndrome
9. Myxoedema coma
10.Non-alcoholic steatohepatitis
JUNE 2007
Paper III
1. Management of suuupraventricular arrhythmias
2. CB1 receptor antagonists and their therapeutic role
3. Continuous ambulatory peritoneal dialysis
4. Obstructive sleep apnoea
5. Recent advances in management of ankylosing spondylosis
6. Complications of falciparum malaria
7. Management of gastrointestinal hemorrhage
8. Recent advances in management of stroke
9. Disseminated intravascular coagulation
10. Syndrome of inappropriate antidiuretic hormone
Paper IV
1. Gene therapy
2. Immune mediated adverse drug reactions to blood transfusions
3. Pharmacological treatment of hyperlipidemia
4. Sickle cell syndrome
5. Meta analysis
6. Sensory tracts in spinal cord and various sensory syndromes
7. Cardiovascular drugs induced lung diseases
8. Randomized control trials
9. Glycemic control and complications: trials in diabetes mellitus
10. Pain management
DECEMBER 2007
Paper I
1. Measures of accuracy of diagnostic tests
2. Principle of clinical ethics
3. Systems of scoring to measure severity of illness in icu and their utility
4. Therapeutic use of botulinium toxin
5. Insulin analogues
6. Clinical features and management of obstructive sleep apnoea
7. Biologicals in inflammatory arthritidies
8. Clinical features of sickle cell hemoglobinopathies
9. Treatment of refractory heart failure
10.Hepatorenal syndrome: pathophysiology and management
Paper II
1. Autoimmune hepatitis
2. Brain abscess
3. Viral haemorrhagic fever
4. Extraintestinal manifestations of ulcerative colitis
5. Lupus nephritis: diagnosis and management
6. Acute respiratory failure: approach and management
7. Management of osteoporosis
8. Tropical pyomyositis
9. Disseminated intravascular coagulation
10.Drug interaction of refampicin
DECEMBER 2007
Paper III
1. Metabolic bone disease
2. Plasmapheresis: role in clinical medicine
3. Channelopathies
4. Posterior circulation stroke
5. Hypothermia: causes clinical features, treatment
6. Pulmonary thromboembolism
7. H. Pylori induced diseases and their treatment
8. Recurrent palpitations: approach and diagnosis
9. Right sided endocarditis
10.HAART
Paper IV
1. Hyperhomocystinemia
2. Metabolic acidosis : diagnosis and approach
3. Blood component therapy
4. Neuroleptic malignant syndrome
5. Hyponatremia
6. Role of probiotics in diseases of gut
7. Pharmacological management of multiple sclerosis
8. Biomedical waste management
9. Postkidney transplantation infection
10. Pathophysiology of ARDS
JUNE 2008
Paper I
1. Describe cardiac pacing – types, indications and complications
2. Thrombophilic state
3. Paraneoplastic endocrine syndrome
4. Drug induced interstitial nephritis – clinical features, lab. Diagnosis and management
5. Febrile jaundice: causes and investigations
6. Post-exposure prophylaxis of rabies
7. Cortical venous thrombosis; risk factors, clinical features and management
8. Reactive arthritis
9. Intermediate syndrome
10.Medical management of obesity
Paper II
1. Wolf Parkinson White syndrome
2. Galactorrhoea
3. Single ring enhancing lesion of brain
4. MDR-TB – Diagnosis and principles of management
5. Hepatopulmonary syndrome
6. Describe myelodysplastic syndrome. Outline classification, clinical features and
diagnosis
7. Immunization in adults
8. Takayasu arteritis – classification, clinical features and management
9. Recurrent falls in elderly – causes and management
10. Scleroderma crisis
JUNE 2008
Paper III
1. Fanconi’s syndrome
2. Poly glandular autoimmune syndrome
3. Right ventricular infarction – diagnosis, management and complications
4. Diagnostic criteria and management of GBS
5. GI manifestations in HIV infection
6. Hypoglycemia: causes and management
7. Tumor lysis syndrome
8. Methaemoglobinemia; causes, clinical features and management
9. Anti phospholipids antibody syndrome
10.Bioterrorism: infective and chemical agents used for it
Paper IV
1. Microalbiminuria: definition and clinical implications
2. Causes of malignancy induced hypercalcemia and its medical management
3. Describe the technique of bronchoalveolar lavage and its applications
4. Principles of parenteral nutrition
5. Interferons: types, clinical uses and adverse effects
6. CNS manifestations of alcohol
7. Describe cytochrome P450 and its relevance in clinical therapeutics
8. Selective gut decontamination
9. Antibiotic resistance
10.Describe the anatomy of the mediastinum. Discuss the common mediastinal masses
and approach to the diagnosis.
DECEMBER 2008
Paper I
1. Management of malaria in pregnancy
2. HIV drug resistance and its prevention
3. Current status of coronary stents and its safety issues
4. Postmenopausal hormone therapy
5. Narcolepsy
6. Current status of stem cell transplantation therapy in clinical medicine
7. Describe MELAS
8. Sjogren's syndrome
9. Solitary Pulmonary Nodule - investigational approach
10.GLP - 1 - Physiological role and therapeutics
Paper II
1. Describe GOLD staging, risk factors and the role of non pharmacological therapies in
COPD.
2. Predictors of severity of acute pancreatitis
3. Role of immunomodulators in MDR TB management.
4. Management of post myocardial infarction tachyarrhythmias.
5. Management of Dengue Shock Syndrome
6. Pseudotumour cerebri
7. Interferons - types and utility in clinical medicine
8. Chikungunya arthritis - pathogenesis and management
9. Pseudohypoparathyroidism
10.Refractory Idiopathic Thrombocytopenic purpura
DECEMBER 2008
Paper III
1. Paraneoplastic pemphigus
2. Describe acute and chronic manifestation of cocaine abuse.
3. Acute radiation sickness and its management
4. Discuss clinical features, staging and treatment of lupus nephritis.
5. Define skin failure and enumerate its causes
6. Toxic epidermal necrolysis - diagnosis and management
7. Chronic Fatigue Syndrome
8. Behcet's syndrome
9. Describe drug treatment of acute mania and bipolar disorders
10.Bioterrorism
Paper IV
1. Describe principles of passive immunisation and their clinical relevance.
2. What are the measures of disease probability and the role of Bayes' theorem in clinical
studies.
3. Discuss the pharmacokinetics of drugs and the factors affecting the pharmacokinetics.
4. Describe the Hasselbach equation. How is pH regulated in human body. Enumerate
High Anion Gap disorders.
5. Management of biomedical waste
6. Describe cerebral circulation. Discuss the pathophysiology and clinical manifestations
of small vessel infarct.
7. Depict the normal flow volume curve and describe the various ventilatory functions
and its clinical implications.
8. Classify glucose lowering therapies used in type 2 diabetes mellitus and their
therapeutic use in regimens.
9. Approach to ANCA interpretation.
10.Elucidate the role of adipocyte in energy regulation. Define obesity and
etiopathogenesis responsible for obesity
JUNE 2009
Paper I
1. Discuss the evaluation of a patient with acute renal failure.
2. Discuss the clinical features , diagnosis and managemant of Wilson,s disease.
3. Critical comment on the benefits and risks of post-menopausal hormone therapy.
4. Write about the effect of pregnancy on valvular heart disease.
5. What are the cause of hypocalcemia? Outline the investigative approach and
management of such case.
6. Discuss the pathophysiology , clinical features and diagnostic tests for gastroesophageal
reflux disease.
7. Current status of myocardial markers.
8. Describe the management of health care personnel who has received a needle stick
injury.
9. Quantification status of obesity.
10.Management of adrenal crisis
Paper II
1. Low molecular weight heparins : their basic and applied considerations.
2. Outline the management of thyroid storm.
3. Management of chronic hepatitis b.
4. Sleep apnea syndrome.
5. Dermatological manifestations of diabetes mellitus.
6. HIV infections and the gut.
7. Management of membranous glomerulonepheritis.
8. Drug induced liver injury.
9. Management of refractory epilepsy.
10.Management of severe and complicated malaria
JUNE 2009
Paper III
1. Describe briefly various pharmacological treatment approaches of alzheimer disease.
2. Describe briefly the motor feature of Parkinson’s Disease.
3. Discuss the etiology , clinical features and management of cortical venous
thrombosis.
4. Discuss the cutaneous manifestations of systemic diseases.
5. Define skin failire and enumerate its causes.
6. Discuss the etiopathogenesis of lichen planus.
7. Discuss the conservative guidelines with respect to the drug treatment of acute mania
and bipolar disorder.
8. Discuss obsessive compulsive neurosis.
9. Discuss in brief mechanical ventilatory support.
10.Briefly discuss the principles of management of organophosphorus poisoning
Paper IV
1. Liposomal drug delivery system.
2. Stem cell therapy.
3. Recent advances in cardiac imaging.
4. Newer insulins.
5. Conducting system of the heart.
6. Chemoprevention of colorectal cancer.
7. Apoptosis.
8. Monoclonal antibodies and their applications.
9. Prion diseases.
10.Null hypothesis.
DECEMBER 2009
PAPER – I
1. What are the benefits and risks of post-menopausal hormone therapy.
2. What are the diagnostic criteria for hypoglycaemia? Describe important causes, clinical
manifestations and principles of management.
3. Define balanced diet. Enumerate various nutritional deficiency disorders and describe the
clinical features and management of protein energy malnutrition.
4. Mention the causes of hyponatremia. Describe the clinical features and management of
SIADH.
5. Mention the causes of osteoporosis. How will you diagnose a case of
Osteoporosis. What are the measures to prevent osteoporosis.
6. Describe the cause and diagnostic evaluation of a patient with chronic diarrohea.
7. Define dementia and delirium. Mention the causes of dementia and comment on the
treatment of demntia.
8. Describe the etiopathogenesis,clinical features and diagnostic evaluation of a patient with
leptospirosis.
9. Describe steroid resistant nephrotic syndrome and its management.
10. Enumerate the diagnostic criteria of systemic lupus erythematous. Describe the emergencoes
in SLE.
PAPER II
1. Classify ataxia disorders. Mention about treatable ataxia. How will you approach a patient
presenting with ataxia.
2. Define hypersensitivity pneumonitis and eosinophilic pneumonia. Describe hypereosinophiic
syndrome and principles of its management.
3. Enumerate various myasthania syndromes along with their differential diagnosis. How will
you manage a patient of myasthenic crisis?
4. What is the who classification of acute myeloid leukaemia? How does it differ from FAB
classification? Describe the prognostic features and line of managemnet for acute
promyelocytic leukaemia.
5. Enumerate various causes of pericarditis. How will you differentiate between restrictive
cardiomyopathy and constrictive pericarditis? Describe the management of constrictive
pericarditis.
6. What are the types of viral hepatitis? Write down characteristic features of hepatitis c illness
and its current line of management.
7. Describe the clinical features,diagnosis and principle of management as well as preventive
measures of acute pulmonary embolism.
8. What is septic shock? Describe its pathopysiology and priciple of management.
9. What is alcoholism? Describe the effects of alcohol on different organ systems and
management of acute alcohol withdrwal.
10. Describe the clinical features and management of venomous snake bite.
DECEMBER 2009
PAPER III
1. What is the significance of CD4 T-cell count in a hiv positive patient? How to start antiretroviral
therapy? What is Immune Reconstitution Inflammatory Syndrome.
2. Define chromosomal sex,gonadal sex and phenotypic sex. Describe the clinical features and
treatment of a patient with Klienfelter Syndrome.
3. Describe the etiology,clinical features and principle of management of acne vulgaris.
4. Describe the clinical features,epidemiology and management of a patient with filariasis.
5. Describe the clinical features and management of lead poisoning.
6. What is unstable psoriasis? Describe the clinical features,diagnostic evaluation and treatment
of a patient of psoriasis.
7. Define paraneoplastic syndrome. Describe the causes and clinical manifeastations of this
condition.
8. Describe the clinical features,diagnostic evaluation and treatment of bipolar disorder.
9. Describe the non-invasive method of ventilatory support and the situations of its use.
Describe the specific strategy of ventilatory management of a patient with COPD.
10. What is aplastic anaemia? Describe the clinical features and principle of management of
aplastic anaemia.
PAPER IV
1. Describe the pathophysiology and haemodynamic consequences of ventricular remodelling.
2. Enumerate various cyanotic heart diseases. Describe the clinical features and management of
a patient with fallot’s tetralogy.
3. Write short notes on importance of extende spectrum beta lactum producing bacteria.
4. Describe bilirubin metabolism. What is the differential diagnosis of obstuctive jaundice?
Describe the diagnostic approach to a 40 yaers old female with obstructive jaundice.
5. Describe the relevance of cytogenetics in clinical medicine with examples.
6. What are the advantages of mri as compared to ct? Enumerate the various contraindications
of mri.
7. Describe the role of inflammatory mediators in bronchial asthama. Enumerate the various ne
drugs available for the treatment of bronchial asthma.
8. What is targeted therapy? What is the basic principle of such therapy? What are the presently
targeted agents available and their uses?
9. Define mean,median and standard deviation. What is the utility of Anova Test? Enumerate
differnet types of research methodologies.
10. Describe the surface anatomy of lung. Enumerate various broncopulmonary segments and
their clinical significance.June 2010
Paper I
1. ARDS – definition, causes and approach to its management
2. Classify lupus nephritis and outline its management
3. Clinical presentation, diagnostic evaluation and management of “right ventricular infarction”
4. Etiology, clinical features and treatment of malignant neuroleptic syndrome
5. Clinical features and management of cardiogenic shock
6. Renij angiotensin system and its role in health and disease
7. Define anion gap. Enumerate causes of metabolic acidosis and mention algorithm for its management
8. Abdominal tuberculosis – types, clinical presentations and diagnostic evaluation
9. Etiological factors, pathophysiology, lab findings and treatment of disseminated intravascular coagulation (DIC)
10. What is parenteral nutrition? What are its hazards and significance in relation to various disorders?
Paper II
1. Causes, clinical manifestation and diagnostic approach of superior vena cava obstruction
2. MDR tuberculosis, diagnostic approach and drug management
3. Pathophysiology, diagnostic evaluation and treatment modalities in primary pulmonary hypertension
4. Clinical presentation of acute methyl alcohol poisoning and its management
5. Classify dyslipidemias and approach to management of hypertriglyceridemias
6. Causes, diagnostic algorithm and management of a patient with thrombocytopenia
7. Define brain death and outline the means of ascertaining brain death
8. Immunopathogenesis of hepatitis B infection and management of chronic hepatitis B
9. Define incretin effect and discuss the incretin mimetics
10. Fundamentals of palliative care
Paper III
1. Clinical features of idiopathic pulmonary fibrosis and its management
2. Enumerate acyanotic congenital heart diseases and describe in brief the clinical features, diagnostic evaluation and treatment of ventricular septal defect
3. Clinical features, diagnostic evaluation and management of neurocysticercosis
4. Clinical features, diagnostic evaluation and treatment of depression
5. Clinical presentation, sequelae and management of herpes zoster
6. Mechanical ventilator – its indications, advantages and complications
7. Enumerate nephrotoxic drugs and describe in brief heir mechanism of toxicity and principles of dose modifications in chronic kidney diseases
8. Define gestational diabetes and outline its management
9. Enumerate geriatric syndromes and outline the management of delirium.
10. Clinical features, diagnostic evaluation and management of hemochromatosis
Paper IV
1. What is evidence based medicine? Describe the various levels of evidence
2. Bioavailability of drugs and enumerate its clinical implications
3. Principles and applications of positron emission tomography (PET) in medicine
4. Enumerate tumor markers in relation to medicine and discuss their clinical applications and limitations
5. Causes investigations and management of acute polyneuropathy
6. Define ventilator associated pneumonias. Enumerate the microbes causing it and outline the treatment approach
7. Pathogenesis, clinical manifestations and acute radiation sickness
8. Biological therapy in rheumatoid arthritis – indications, contraindications and monitoring
9. Describe pulmonary function tests and their interpretation in relation to various pulmonary diseases
10. Anatomy of ‘cortical venous sinuses’ and outline the management of cavernous sinus thrombosis
DNB GENERAL MEDICINE QUESTION PAPERS
JANUARY 2000
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